CGRP Education & Research Forum
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Backgrounders

Unmet needs in migraine prevention

Migraine is a complex chronic neurovascular disorder characterised by recurrent moderate to severe headaches with a number of associated symptoms. Both genetic and environmental factors are known to play a part in the disorder.

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CGRP and migraine

The neuropeptide calcitonin gene-related peptide (CGRP) is a very potent vasodilator which plays a major role in migraine pathophysiology. It was first identified over 30 years ago and is found as two isoforms, one in the peripheral nervous and central nervous system (α-CGRP) and the other (β-CGRP) mainly in the enteric nervous system surrounding the intestines.

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