CGRP Education & Research Forum
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CGRP therapies work better in clinical practice than in trials

CGRP therapies have proved more effective in clinical practice than in trials, though adverse events (AEs) and discontinuations are more common. There is potential for both rapid and delayed responses, and there appear to be additive and synergistic effects between CGRP therapies and other preventive treatments such as botulinum toxin. These were the main conclusions …

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Erenumab five-year data support long term use in migraine

Long-term erenumab treatment up to five years has demonstrated sustained reductions in migraine frequency with no new safety signals, according to latest data from an open label treatment phase (OLTP) following a 12-week double-blind treatment phase (DBTP) in patients with episodic migraine. Of 383 patients enrolled in the OLTP, 250 switched from erenumab 70 mg …

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Exploring ‘wearing off’ in galcanezumab trials

Fewer than one in 10 patients with high frequency episodic migraine (HFEM) or chronic migraine (CM) who took part in four major galcanezumab trials exhibited ‘wearing off’ signs during the final week of each treatment cycle. This is the conclusion from an exploratory analysis of data from the EVOLVE-1 and -2, REGAIN and CONQUER trials. …

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FOCUS analyses show sustained benefits of fremanezumab and favourable NNT and NNH data

Fremanezumab has demonstrated sustained efficacy and tolerability with up to six months treatment in the Phase 3B FOCUS study of patients with episodic migraine (EM) or chronic migraine (CM) who had inadequate response to 2-4 classes of prior migraine preventive medication classes.1 A further analysis of 12-week data from the trial has shown that number …

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Risk factors for inpatient constipation in new erenumab users

Patients requiring inpatient treatment for constipation within 90 days of starting erenumab treatment are likely to be older (> 65 years), or to have had prior constipation or complications of constipation, or baseline constipation risk factors other than multiple sclerosis.1 These are the conclusions of an analysis carried out on 9,994 new patients aged > …

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Atogepant has no clinically relevant interactions with sumatriptan or OTC analgesics

Non-clinically relevant changes have been reported in pharmacokinetic (PK) studies of atogepant coadministered with sumatriptan, acetaminophen or naproxen. In a Phase 1 pharmacokinetic study of atogepant and sumatriptan in 30 healthy adults, the median time for atogepant to achieve maximum plasma concentration (Tmax) was delayed by 1.5 hours when the drug was coadministered with sumatriptan …

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Preventive therapies do not affect ubrogepant efficacy, tolerability or pharmacokinetics

Patients using ubrogepant can expect the same efficacy and tolerability in treating their migraine attacks, irrespective of whether they are taking preventive therapies. Taking erenumab or galcanezumab with ubrogepant does not appear to affect ubrogepant pharmacokinetics. These are the findings from two presentations reporting coadministration of ubrogepant and preventive therapies. Data from the ACHIEVE trials …

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