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CGRP hypersensitivity may predict anti-CGRP treatment responders

Patients who respond well to erenumab are highly susceptible to CGRP provocation, according to results of a small study to explore a possible correlation between individual efficacy of anti-CGRP treatment and susceptibility to migraine induction by CGRP. Ten high responders to erenumab were included in the study and three poor responders. CGRP induced migraine-like attacks …

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Galcanezumab equally effective for low- and high-frequency episodic migraine

Treatment effects of both doses of galcanezumab in reducing monthly migraine headache days and disability and improving function are similar for patients with low- and high-frequency episodic migraine, according to an analysis of pooled data from the EVOLVE-1 and EVOLVE-2 studies. Headaches were tracked by low-frequency (LFEM: 4-7 monthly migraine headache days [MHDs]) or high-frequency …

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DNA methylation study sheds new light on CGRP gene involvement in migraine

Preliminary data suggest that DNA methylation of part of the promoter region of the CALCA gene which encodes CGRP is different in patients with migraine, compared to those who do not have the disease. DNA methylation is the most common modification of epigenetic markers – heritable changes in phenotype or gene expression in the absence …

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Fremanezumab data confirm efficacy in patients with previous prophylaxis failure

Fremanezumab has been shown to improve multiple efficacy parameters in patients who failed at least one previous preventive medication, including monthly migraine days, need for acute migraine medication, and disability, in a series of analyses of Phase 3 trials in episodic and chronic migraine.1-3 In one study of episodic migraine, a greater proportion of patients …

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CGRP study highlights potential mechanistic differences between episodic and chronic cluster headache

A new investigation of levels of CGRP, vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) in patients with episodic and cluster headache has suggested basic pathophysiological differences between the two conditions.1 In the randomised, double-blind, placebo controlled, two-way crossover study, CGRP, VIP and PACAP-38 measurements were reported at baseline, in response to …

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Neck pain is more likely a symptom of migraine than a trigger

Neck pain/tension is more likely to be a symptom of migraine than a trigger, according to digital diary data from 774 patients with migraine who recorded their headaches along with information about potential contributory factors. Among respondents, 21% considered that neck pain/tension was associated with increased risk of migraine, and none thought it was protective. …

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Excessive yawning linked to increased migraine risk in a quarter of patients

Excessive yawning could be used as an early warning for migraine attacks in susceptible individuals and enable rapid intervention, conclude the authors of a study investigating this common premonitory migraine symptom. Results of a digital diary study in 852 patients, 285 of whom were eligible for analysis, showed that excessive yawning was associated with increased …

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